top of page

CYY's Laboratory of RNA Biology &
Molecular Virology

Molecular
Virologist

For over a decade, our team has been deeply immersed in studying the fascinating interplay between host factors and positive-sense RNA viruses, with a primary focus on Orthoflaviviruses. Our research has been dedicated to dissecting the intricate mechanisms and practical implications of viral proteases as they cleave cellular substrates at the molecular level. Through our endeavors, we've nurtured a skilled team proficient in molecular biotechnology, particularly specializing in RNA and viruses. Additionally, as a mission-oriented laboratory, we've been actively engaged in RNA-related mission studies during the global response to the COVID-19 pandemic, furthering our commitment to serve society with science.

a cis_edited_edited.jpg

A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning

a cis_edited_edited.jpg

Chan-I Su, Zih-Shiuan Chuang, Chi-Ting Shie, Hsin-I Wang, Yu-Ting Kao & Chia-Yi Yu
Nature Communications volume 15,
Article number: 6607 (2024)

FIG2_edited.jpg
FOG4_edited.jpg
a cis_fig1_edited.jpg
Contact

Research Interests

R-1.png
  • RESEARCH TOPICS

  1. Molecular Virology
    -Biology of flaviviruses, mostly dengue virus (DENV)
    -Recombination & reverse genetics of RNA viruses

  2. Recombination & reverse genetics of RNA viruses
    -Viral RNA biology and translation regulation
    -circular RNA design and functioning
    -RNA vaccine

  3. Viral/cellular factors regulating innate immunity
    -cGAS/STING-mediated signaling pathways
    -RIG-I/MDA5/MAVS-mediated pathways
    -Inflammasome activation pathways 

  4. Virus-host interactions
    -ER stress and unfolded protein responses (UPR)
    -Death signaling pathways
    -Mitochondrial biology and mitochondrial-associated pathways
    -Metabolic pathways

Publications

h-5.png

A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning.

Nature Communications volume 15, Article number: 6607 (2024)

Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model.

Mol Ther Oncolytics. 2023 Jan 2;28:104-117

DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease.

Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15947-15954.

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.

PLoS Pathogens 2015 Dec 11(12): e1005350.

Dengue virus targets the adaptor protein MITA to subvert host innate immunity.

PLoS Pathogens (2012) Jun 8(6): e1002780.

Contact Information

National Institute of Infectious Diseases and Vaccinology

National Health Research Institutes (NHRI), Taiwan

Lab location

(NHRI Tainan Campus)

web.png
bottom of page