CYY's Laboratory of RNA Biology &
Molecular Virology
Molecular
Virologist
For over a decade, our team has been deeply immersed in studying the fascinating interplay between host factors and positive-sense RNA viruses, with a primary focus on Orthoflaviviruses. Our research has been dedicated to dissecting the intricate mechanisms and practical implications of viral proteases as they cleave cellular substrates at the molecular level. Through our endeavors, we've nurtured a skilled team proficient in molecular biotechnology, particularly specializing in RNA and viruses. Additionally, as a mission-oriented laboratory, we've been actively engaged in RNA-related mission studies during the global response to the COVID-19 pandemic, furthering our commitment to serve society with science.
A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning
Chan-I Su, Zih-Shiuan Chuang, Chi-Ting Shie, Hsin-I Wang, Yu-Ting Kao & Chia-Yi Yu
Nature Communications volume 15,
Article number: 6607 (2024)
Research Interests
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RESEARCH TOPICS
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Biology of flaviviruses
-mostly dengue virus (DENV)
-Viral RNA biology and translation regulation -
RNA design
-circular RNA functioning
-RNA vaccines -
Virus-host interactions
signaling pathways:
-cGAS/STING-mediated pathways
-RIG-I/MDA5/MAVS-mediated pathways
-Inflammasome activation pathways
-ER stress and unfolded protein responses (UPR)
-Death signaling pathways
-Mitochondrial biology and mitochondrial-associated pathways
Publications
A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning.
Nature Communications volume 15, Article number: 6607 (2024)
Zika virus cleaves GSDMD to disseminate prognosticable and controllable oncolysis in a human glioblastoma cell model.
Mol Ther Oncolytics. 2023 Jan 2;28:104-117
DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease.
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15947-15954.
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
PLoS Pathogens 2015 Dec 11(12): e1005350.
Dengue virus targets the adaptor protein MITA to subvert host innate immunity.
PLoS Pathogens (2012) Jun 8(6): e1002780.